Methodology for awakening the potential secondary metabolic capacity in actinomycetes

• Shun Saito and
• Midori A. Arai

Beilstein J. Org. Chem. 2024, 20, 753–766, doi:10.3762/bjoc.20.69

• , and the associated undiscovered secondary metabolite biosynthesis genes are called “silent” genes. This review outlines several approaches to further activate the metabolic potential of actinomycetes. Keywords: actinomycete; co-culture; heat shock metabolites (HSMs); secondary metabolites; silent

• of silent genes. The authors’ group has been working on methods to activate these genes by increasing the culture temperature above the normal level. Temperature – heat-shock metabolites (HSMs) – metabolites for which production is activated by high-temperature culture Several examples of high